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KMID : 1007520220310101335
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Food Science and Biotechnology
2022 Volume.31 No. 10 p.1335 ~ p.1342
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Roasted garlic protects against leaky gut syndrome in dextran sodium sulfate-induced colitis mice
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Sharma Divya
Sangar Madhuri
Park Jeom-Leon
Kang Seong-Gook
Ham Kyung-Sik
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Abstract
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Garlic (Allium sativum) is a potentially beneficial functional food that is extensively grown around the globe. We have investigated the effect of roasted garlic on a dextran sodium sulfate (DSS)-induced intestinal permeability model in mice. Mice were divided into four diet groups: CON, DSS, RG (roasted garlic), and RG?+?Purple bamboo salt (RGP) in the AIN 93G diet for 3 weeks. All groups except the CON group received 2% DSS in drinking water at the last week of the experiment. DSS groups showed significantly elevated gut permeability levels and decreased tight junction protein expression compared to CON. However, RG and RGP displayed remarkably lower trends of gut permeability, increased tight junction protein expression, increased number of goblet cells than the DSS group in hematoxylin and eosin and alcian blue-nuclear fast red stained colon sections. These results indicate that roasted garlic could prevent gut leakage induced by DSS.
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KEYWORD
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Gut permeability, Tight junctions, Goblet cells, Purple bamboo salt
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